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KMID : 0358619760100020023
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Korean Journal of Physiology
1976 Volume.10 No. 2 p.23 ~ p.28
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Effects of Sodium Restrietion and Potassium Supplement on Aldosterone Secretion Rate in the Normal Korean
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Abstract
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Author have already reported that urinary aldosterone excretion of the Korean who usually eat high sodium diet is significantly lower comparing with the American, although the plasma aldosterone concentration is identical in the former with that of the latter.
Measurement of urinary aldosterone excretion and plasma concentration only is insufficient to establish the pressence and/or mode of evolution of the Korean.
In this experiments, aldosterone secretion rateCASR) was measured in normotensive Korean
during high and low dietary sodium intake with or without additional potassium supply.
Results were as follows;
1) In normal Korean, dietary sodium restriction resulted in appreciable increase in ASR, and a sustained increase in urinary aldosterone excretion with an increase in plasma level.
2) Oral potassium loading easily stimulated the adrenal cortex of the Korean who already adapted to a high sodium diet when dietary sodium is still identical with normal American.
3) Quantitative relationships between aldosterone secretion rate, plasma concentration and urinary excretion of aldosterone were altered by potassium loading.
4) Urinary aldosterone excretion didn´t reflect concurrent increase aldosterone secretion in subjects with potassium intake.
It was discussed that the changes of the relationships and of adrenal hyper response on potassium loading in the Korean will be elucidated by measuring the metabolic clearance rate.
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